Antigen processing and presentation of exogenous peptide antigen

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of exogenous peptide antigen pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8, HLA-A, and HLA-B, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of exogenous peptide antigen activity versus PSMB8 in SOFT_TISSUE (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PSMB8 →	+5.638	+1.563	<.001	.001	3	17
BLOOD_Lymphoma	HLA-A →	+3.208	+1.453	<.001	<.001	3	16
OESOPHAGUS	HLA-B →	+3.417	+0.558	.001	<.001	3	15
LUNG_SCLC	HLA-C →	+4.463	+0.737	<.001	.008	3	15
LARGE_INTESTINE	B2M →	+2.609	+0.494	<.001	<.001	3	14
BONE	PSMB9 →	+4.372	+0.701	.003	.003	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002478 vs PSMB8 — SOFT_TISSUE

Explore this scatter interactively →