Antigen processing and presentation via MHC class Ib

Across TCGA patient cohorts, RNA activity of the Antigen processing and presentation via MHC class Ib pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL9, TNFSF13B, and IFNG, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation via MHC class Ib activity versus CXCL9 in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CXCL9 →	+2.043	+0.203	<.001	<.001	3	10
HNSC	TNFSF13B →	+0.818	+0.257	<.001	<.001	3	9
HNSC	IFNG →	+1.046	+0.273	<.001	<.001	3	9
HNSC	STAT1 →	+0.894	+0.276	<.001	<.001	3	9
HNSC	PARP9 →	+0.744	+0.243	<.001	<.001	3	9
HNSC	GBP4 →	+1.285	+0.318	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002475 vs CXCL9 — HNSC

Explore this scatter interactively →