Dendritic cell antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Dendritic cell antigen processing and presentation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARSB, MFHAS1, and RARS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARSB grouped by Dendritic cell antigen processing and presentation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ARSB →	-0.217	-1.945	<.001	.005	3	3
LARGE_INTESTINE	MFHAS1 →	-0.193	-0.593	<.001	.007	3	3
LUNG_NSCLC_LUAD	RARS1 →	-0.182	-0.781	.002	.001	3	3
LUNG_NSCLC_LUAD	PEMT →	-0.164	-1.096	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	OR2M1P →	+0.174	+1.856	.001	.003	3	3
BLOOD_Myeloma	SYT3 →	-0.185	-1.775	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARSB by Dendritic cell antigen processing and presentation activity — BLOOD_Myeloma

Explore this box plot interactively →