Germinal center formation

Across TCGA patient cohorts, RNA activity of the Germinal center formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SAMHD1, and SAMSN1_S107, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Germinal center formation activity versus RCSD1 in OV (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1 →	+0.696	+0.076	<.001	<.001	3	10
LSCC	SAMHD1 →	+0.525	+0.152	<.001	<.001	3	10
UCEC	SAMSN1_S107 →	+0.924	+0.154	<.001	<.001	3	10
OV	SASH3 →	+0.558	+0.080	<.001	<.001	3	10
OV	SEPTIN1 →	+0.934	+0.073	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.833	+0.128	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002467 vs RCSD1 — OV

Explore this scatter interactively →