Germinal center formation

Across TCGA patient cohorts, RNA activity of the Germinal center formation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL13, ZSWIM5, and CYTIP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Germinal center formation activity versus CXCL13 in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CXCL13 →	+1.394	+0.557	<.001	.003	3	6
UCEC	ZSWIM5 →	-0.799	-0.715	.001	<.001	3	6
LUAD	CYTIP →	+0.536	+0.576	<.001	.001	3	6
COAD	VIPR1 →	-0.780	-0.462	<.001	.001	3	5
GBM	SAT1 →	+0.744	+0.712	<.001	.003	3	5
UCEC	SOD2 →	+1.039	+0.660	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002467 vs CXCL13 — COAD

Explore this scatter interactively →