Germinal center formation

Across TCGA cell cohorts, RNA activity of the Germinal center formation pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Camptothecin, Nilotinib, and Refametinib, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Camptothecin grouped by Germinal center formation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Camptothecin →	+0.600	+2.653	.043	.001	1	1
BLOOD_Leukemia	Nilotinib →	+0.770	+2.653	.048	.001	1	1
BLOOD_Leukemia	Refametinib →	+1.130	+2.653	.045	.001	1	1
BLOOD_Leukemia	Axitinib →	+1.274	+2.653	.016	.001	1	1
BLOOD_Leukemia	Nutlin-3a (-) →	+1.484	+2.653	.001	.001	1	1
BLOOD_Leukemia	ZM447439 →	+1.164	+2.653	.041	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Camptothecin by Germinal center formation activity — BLOOD_Leukemia

Explore this box plot interactively →