T cell antigen processing and presentation

pathway activity — cross-omics
GO:0002457Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the T cell antigen processing and presentation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D10C, DEF6, and DOCK10_T1440, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADTBC1D10C →+0.647+0.085<.001.001310
GBMDEF6 →+0.641+0.160<.001<.001310
HNSCDOCK10_T1440 →+0.984+0.142<.001<.001310
UCECFERMT3 →+0.668+0.105<.001<.001310
GBMFGL2 →+0.916+0.151<.001<.001310
BRCAHLA-DPB1 →+0.643+0.096<.001<.001310
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration