Humoral immune response mediated by circulating immunoglobulin

Across TCGA patient cohorts, RNA activity of the Humoral immune response mediated by circulating immunoglobulin pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, ADA2, and HCLS1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Humoral immune response mediated by circulating immunoglobulin activity versus WIPF1 in UCEC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WIPF1 →	+0.410	+0.122	<.001	<.001	3	10
LSCC	ADA2 →	+0.601	+0.079	<.001	<.001	3	10
GBM	HCLS1 →	+0.846	+0.115	<.001	<.001	3	10
GBM	LCP1 →	+0.825	+0.107	<.001	<.001	3	10
GBM	LPXN →	+0.605	+0.088	<.001	<.001	3	10
GBM	LSP1 →	+0.642	+0.080	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002455 vs WIPF1 — UCEC

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