Inflammatory response to antigenic stimulus

Across TCGA cell cohorts, RNA activity of the Inflammatory response to antigenic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB2, PIAS2, and C4orf46, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammatory response to antigenic stimulus activity versus HMGB2 in BREAST (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HMGB2 →	+1.086	+0.222	<.001	<.001	3	8
BLOOD_Leukemia	PIAS2 →	+0.809	+0.142	<.001	<.001	3	5
LUNG_SCLC	C4orf46 →	+0.941	+0.234	<.001	<.001	3	5
BREAST	SPINDOC →	+1.000	+0.241	.002	.003	3	5
LUNG_SCLC	LCORL →	+0.852	+0.194	.001	.002	2	6
LUNG_SCLC	PAN3 →	+0.806	+0.128	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002437 vs HMGB2 — BREAST

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