T cell lineage commitment

Across TCGA cell cohorts, RNA activity of the T cell lineage commitment pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST4, MYBL2, and ITGAV, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHST4 grouped by T cell lineage commitment-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CHST4 →	-0.321	-0.226	.001	.009	3	6
UPPER_AERODIGESTIVE_TRACT	MYBL2 →	-0.618	-0.242	<.001	.002	3	6
CNS	ITGAV →	+0.283	+0.116	.007	.001	3	5
BLOOD_Leukemia	RASL11B →	-0.275	-0.154	<.001	<.001	3	4
LUNG_NSCLC_LUAD	MED19 →	-0.201	-0.166	.003	.005	2	5
LIVER	ATOX1 →	-0.275	-0.235	.009	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHST4 by T cell lineage commitment activity — SOFT_TISSUE

Explore this box plot interactively →