Immature B cell differentiation

Across TCGA patient cohorts, RNA activity of the Immature B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL23AP61, POP1, and CBL, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immature B cell differentiation activity versus RPL23AP61 in LSCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPL23AP61 →	-0.077	-0.857	<.001	<.001	3	3
LUAD	POP1 →	+0.509	+0.762	<.001	<.001	3	3
UCEC	CBL →	+0.391	+0.784	.001	.001	3	3
PDAC	LINC01760 →	-0.115	-0.699	.004	.003	3	3
COAD	NINL →	+0.880	+0.592	.001	.005	3	2
COAD	PMPCB →	+0.154	+0.547	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002327 vs RPL23AP61 — LSCC

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