Natural killer cell activation involved in immune response

Across TCGA patient cohorts, RNA activity of the Natural killer cell activation involved in immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP2, LSP1, and ARHGAP15, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Natural killer cell activation involved in immune response activity versus LCP2 in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCP2 →	+0.546	+0.092	<.001	<.001	3	9
GBM	LSP1 →	+0.871	+0.114	<.001	<.001	3	9
GBM	ARHGAP15 →	+0.601	+0.083	<.001	<.001	3	9
OV	ARHGAP45 →	+0.576	+0.092	<.001	<.001	3	9
GBM	PLCB2 →	+0.384	+0.090	<.001	<.001	3	9
GBM	SIPA1 →	+0.325	+0.089	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002323 vs LCP2 — GBM

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