B cell proliferation involved in immune response

Across TCGA cell cohorts, RNA activity of the B cell proliferation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM19, NDUFC2, and TBC1D4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM19 grouped by B cell proliferation involved in immune response-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMEM19 →	+1.095	+1.956	.009	<.001	2	3
OVARY	NDUFC2 →	+0.946	+1.930	.002	<.001	2	3
LUNG_SCLC	TBC1D4 →	+1.689	+0.767	<.001	.004	3	2
LUNG_SCLC	TAS2R50 →	+0.150	+1.014	<.001	.002	3	2
LUNG_SCLC	SLC46A1 →	+0.887	+1.023	<.001	.004	3	2
LUNG_NSCLC_LUAD	C1orf54 →	+0.395	+0.554	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM19 by B cell proliferation involved in immune response activity — OVARY

Explore this box plot interactively →