Lymphoid progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Lymphoid progenitor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3, S100A14, and SEPTIN4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphoid progenitor cell differentiation activity versus SORBS3 in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SORBS3 →	+0.389	+0.064	<.001	<.001	3	7
HNSC	S100A14 →	-0.836	-0.070	<.001	<.001	3	7
PDAC	SEPTIN4 →	+0.404	+0.039	<.001	<.001	3	7
BRCA	STXBP1 →	+0.569	+0.060	<.001	<.001	3	7
BRCA	CLUH →	-0.420	-0.053	<.001	.001	3	7
OV	RPL7 →	-0.357	-0.051	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002320 vs SORBS3 — BRCA

Explore this scatter interactively →