Lymphoid progenitor cell differentiation

Across TCGA cell cohorts, RNA activity of the Lymphoid progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBN2, MRPL2, and RIOK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBN2 grouped by Lymphoid progenitor cell differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FBN2 →	-6.096	-1.755	.008	.001	3	5
BLOOD_Lymphoma	MRPL2 →	+0.641	+1.772	.003	<.001	3	4
BLOOD_Lymphoma	RIOK1 →	+1.433	+1.990	.007	<.001	2	5
BLOOD_Lymphoma	RBSN →	+0.430	+1.772	.009	<.001	3	4
BLOOD_Lymphoma	BRD2 →	+1.216	+1.907	.003	<.001	3	4
BONE	SUOX →	-1.728	-1.393	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBN2 by Lymphoid progenitor cell differentiation activity — URINARY_TRACT

Explore this box plot interactively →