Marginal zone B cell differentiation

Across TCGA patient cohorts, RNA activity of the Marginal zone B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD37, IGSF6, and TRG-AS1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Marginal zone B cell differentiation activity versus CD37 in OV (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD37 →	+0.944	+0.853	.003	<.001	3	10
BRCA	IGSF6 →	+0.752	+0.809	<.001	<.001	3	10
LSCC	TRG-AS1 →	+0.558	+0.558	<.001	<.001	3	10
HNSC	GRAP2 →	+0.808	+0.698	<.001	<.001	3	9
HNSC	EBI3 →	+0.931	+0.650	<.001	.001	3	9
HNSC	PIK3CG →	+1.109	+0.908	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002315 vs CD37 — OV

Explore this scatter interactively →