Germinal center B cell differentiation

Across TCGA cell cohorts, RNA activity of the Germinal center B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARG1, WFDC3, and KCNS2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Germinal center B cell differentiation activity versus ARG1 in BLOOD_Lymphoma (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARG1 →	+0.170	+1.203	.003	.004	3	1
BLOOD_Lymphoma	WFDC3 →	+0.350	+1.019	<.001	.005	3	1
BLOOD_Lymphoma	KCNS2 →	+0.022	+1.385	.003	<.001	3	1
BLOOD_Lymphoma	CCDC189 →	+1.412	+1.210	.004	.004	3	1
BLOOD_Lymphoma	RPS6KL1 →	+1.632	+0.822	.005	.006	3	1
BLOOD_Lymphoma	HOXB7 →	+1.495	+1.231	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002314 vs ARG1 — BLOOD_Lymphoma

Explore this scatter interactively →