B cell activation involved in immune response

Across TCGA patient cohorts, RNA activity of the B cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELLS, NCAPH, and CENPK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell activation involved in immune response activity versus HELLS in GBM (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HELLS →	+0.990	+0.905	<.001	.001	3	7
BRCA	NCAPH →	+0.799	+0.883	<.001	<.001	3	7
GBM	CENPK →	+0.873	+0.800	<.001	.001	3	7
UCEC	SGO1 →	+0.872	+0.530	.001	.007	3	7
GBM	RAD54L →	+0.767	+0.895	<.001	.001	3	7
BRCA	LMNB1 →	+0.805	+0.826	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002312 vs HELLS — GBM

Explore this scatter interactively →