T cell differentiation involved in immune response

Across TCGA cell cohorts, RNA activity of the T cell differentiation involved in immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNJ18, CTSH, and ALDH4A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNJ18 grouped by T cell differentiation involved in immune response-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KCNJ18 →	+0.175	+0.097	.001	<.001	3	5
SOFT_TISSUE	CTSH →	-0.256	-0.135	.009	.001	3	5
LIVER	ALDH4A1 →	-0.131	-0.117	.003	<.001	3	4
BREAST	CDKL5 →	+0.170	+0.138	<.001	<.001	3	4
BLOOD_Lymphoma	TWIST1 →	-0.305	-0.048	.002	.006	3	4
SOFT_TISSUE	ABCA9 →	-0.204	-0.132	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNJ18 by T cell differentiation involved in immune response activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →