T cell activation involved in immune response

Across TCGA patient cohorts, RNA activity of the T cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SP140, WAS, and FYB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell activation involved in immune response activity versus SP140 in COAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SP140 →	+0.752	+0.797	<.001	.001	3	9
GBM	WAS →	+0.696	+0.886	<.001	<.001	3	9
GBM	FYB1 →	+1.024	+0.921	<.001	<.001	3	9
OV	SCIMP →	+0.580	+0.315	.002	.008	2	9
OV	NCF1B →	+0.788	+0.320	.002	.007	3	8
COAD	LCP2 →	+0.952	+0.705	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002286 vs SP140 — COAD

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