T cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the T cell activation involved in immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPO, BRD2, and CDK13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNPO grouped by T cell activation involved in immune response-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PNPO →	+0.144	+0.105	.001	<.001	3	5
LIVER	BRD2 →	+0.305	+0.160	.006	<.001	3	4
BREAST	CDK13 →	-0.219	-0.091	<.001	<.001	3	4
BREAST	CDKL5 →	+0.147	+0.117	.002	<.001	3	4
LUNG_NSCLC_LUAD	CBLL1 →	-0.220	-0.082	<.001	.005	3	4
BREAST	ACLY →	-0.358	-0.121	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNPO by T cell activation involved in immune response activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →