Lymphocyte activation involved in immune response

Across TCGA patient cohorts, RNA activity of the Lymphocyte activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB5AP2, ASIP, and PATL2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte activation involved in immune response activity versus CYB5AP2 in OV (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYB5AP2 →	+0.244	+0.991	.003	<.001	3	2
COAD	ASIP →	+0.333	+0.927	<.001	<.001	3	2
BRCA	PATL2 →	+0.859	+0.982	<.001	.005	3	2
BRCA	CLEC2D →	+1.042	+1.228	<.001	<.001	3	2
OV	RHOXF1 →	+0.475	+0.845	.004	.006	3	1
OV	PQBP1 →	+0.402	+0.852	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002285 vs CYB5AP2 — OV

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