Lymphocyte activation involved in immune response

Across TCGA pan-cancer cohorts, RNA activity of the Lymphocyte activation involved in immune response pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 213 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Lymphocyte activation involved in immune response pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

HNSC, LUAD, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.766	0.646	<.001	122	view →
LUAD	OS	Median	All	0.769	0.627	<.001	89	view →
SKCM	OS	Median	All	0.451	0.265	<.001	82	view →
CESC	OS	Quartile	All	0.897	0.724	.004	50	view →
UVM	DFS	Quartile	All	0.284	0.702	<.001	49	view →
DLBC	DFS	Tertile	All	0.120	0.913	.001	42	view →
LGG	OS	Tertile	All	0.400	0.616	<.001	42	view →
ACC	OS	Median	III,IV	0.147	0.528	<.001	41	view →
LAML	DFS	Tertile	All	0.231	0.534	.001	30	view →
KIRC	DFS	Tertile	All	0.520	0.683	.002	30	view →
PAAD	OS	Median	II,III,IV	0.692	0.505	.003	21	view →
CHOL	DFS	Median	All	0.652	0.268	.015	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0002285–HNSC (DFS)

Open the HNSC breakdown →