Lymphocyte activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Lymphocyte activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQLE, PXYLP1, and PIAS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SQLE grouped by Lymphocyte activation involved in immune response-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SQLE →	-2.087	-0.334	.001	.003	3	4
BONE	PXYLP1 →	-1.585	-0.319	<.001	<.001	3	4
BONE	PIAS2 →	-0.754	-0.252	.002	.007	3	4
LUNG_SCLC	ITGA5 →	+2.268	+0.139	.007	.002	3	4
LUNG_SCLC	MEMO1 →	+0.781	+0.181	.006	.002	3	4
LUNG_SCLC	SGMS2 →	+2.276	+0.175	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SQLE by Lymphocyte activation involved in immune response activity — BONE

Explore this box plot interactively →