Lymphocyte activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Lymphocyte activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHMT1, LAMP3, and BLVRA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte activation involved in immune response activity versus SHMT1 in BLOOD_Myeloma (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SHMT1 →	+1.157	+0.172	.001	<.001	3	7
KIDNEY	LAMP3 →	-0.943	-0.179	.006	<.001	3	6
BLOOD_Lymphoma	BLVRA →	+3.671	+0.244	<.001	<.001	3	6
LIVER	MRM3 →	+0.791	+0.383	.005	.003	3	6
OVARY	CHST7 →	+1.775	+0.377	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ATP6V0E2 →	+1.704	+0.511	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002285 vs SHMT1 — BLOOD_Myeloma

Explore this scatter interactively →