Lymphocyte activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Lymphocyte activation involved in immune response pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB3, PSMB2, and PSMB4, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte activation involved in immune response activity versus PSMB3 in URINARY_TRACT (Pearson r = 0.86).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PSMB3 →	+1.228	+0.403	<.001	<.001	3	20
URINARY_TRACT	PSMB2 →	+1.164	+0.428	<.001	<.001	3	20
URINARY_TRACT	PSMB4 →	+1.332	+0.412	<.001	<.001	3	19
OESOPHAGUS	PSMA3 →	+1.451	+0.427	<.001	<.001	3	18
URINARY_TRACT	PSMA6 →	+1.436	+0.429	<.001	<.001	3	18
STOMACH	PSMA2 →	+1.318	+0.664	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002285 vs PSMB3 — URINARY_TRACT

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