Neutrophil activation involved in immune response

Across TCGA patient cohorts, RNA activity of the Neutrophil activation involved in immune response pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APOBR, PTPN6, and ITGAX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil activation involved in immune response activity versus APOBR in LSCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	APOBR →	+0.553	+0.070	<.001	<.001	3	8
GBM	PTPN6 →	+0.474	+0.060	<.001	<.001	3	8
UCEC	ITGAX →	+0.639	+0.073	<.001	<.001	3	8
GBM	MYO1G →	+0.528	+0.066	<.001	<.001	3	8
LSCC	RENBP →	+0.528	+0.069	<.001	<.001	3	7
COAD	S100A4 →	+0.564	+0.032	.005	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002283 vs APOBR — LSCC

Explore this scatter interactively →