Neutrophil activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Neutrophil activation involved in immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMBR1, H2BC8, and SLC22A18AS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LMBR1 grouped by Neutrophil activation involved in immune response-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LMBR1 →	-0.344	-2.072	.002	<.001	3	4
BLOOD_Lymphoma	H2BC8 →	+0.400	+1.640	.003	<.001	3	3
LUNG_SCLC	SLC22A18AS →	+0.300	+1.271	<.001	.004	3	3
LUNG_SCLC	DHRS9 →	+0.169	+1.076	.002	.008	3	3
CNS	ERCC2 →	-0.301	-1.171	.004	.002	3	3
BLOOD_Leukemia	TNPO2 →	+0.295	+1.812	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMBR1 by Neutrophil activation involved in immune response activity — STOMACH

Explore this box plot interactively →