Neutrophil activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Neutrophil activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCEH1, ANXA3, and RHOA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil activation involved in immune response activity versus NCEH1 in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NCEH1 →	+2.029	+1.456	<.001	.001	3	6
LUNG_NSCLC_LUSC	ANXA3 →	+3.449	+1.672	.005	.009	2	7
OESOPHAGUS	RHOA →	+0.855	+1.505	.002	<.001	3	5
OESOPHAGUS	BDNF →	+1.252	+1.164	.004	<.001	3	5
BREAST	ARPC2 →	+0.581	+0.893	.003	.004	3	5
BREAST	WDR1 →	+1.109	+1.115	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002283 vs NCEH1 — LIVER

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