Macrophage activation involved in immune response

Across TCGA patient cohorts, RNA activity of the Macrophage activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC9, CD300C, and LILRB4, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage activation involved in immune response activity versus SIGLEC9 in LAML (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	SIGLEC9 →	+1.959	+0.079	<.001	<.001	3	34
LAML	CD300C →	+1.871	+0.095	<.001	<.001	3	34
LAML	LILRB4 →	+1.775	+0.068	<.001	<.001	3	34
SARC	HCK →	+1.607	+0.060	<.001	<.001	3	33
SCLC	CD33 →	+1.618	+0.171	<.001	<.001	3	33
LAML	MS4A6A →	+2.120	+0.081	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002281 vs SIGLEC9 — LAML

Explore this scatter interactively →