Macrophage activation involved in immune response

Across TCGA pan-cancer cohorts, RNA activity of the Macrophage activation involved in immune response pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Macrophage activation involved in immune response pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and SARC, show the opposite pattern, with higher activity associated with better survival.

READ, SKCM, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Quartile	All	0.341	0.713	.001	63	view →
SKCM	OS	Tertile	All	0.448	0.272	<.001	49	view →
UCEC	OS	Median	All	0.904	0.941	.003	48	view →
COAD	OS	Median	All	0.456	0.642	.004	34	view →
OV	OS	Tertile	III,IV	0.637	0.750	.006	32	view →
UVM	DFS	Quartile	All	0.339	0.630	.014	26	view →
LGG	DFS	Median	All	0.676	0.790	.002	21	view →
LAML	DFS	Tertile	All	0.265	0.532	.015	20	view →
SARC	DFS	Tertile	All	0.644	0.375	.007	20	view →
CESC	DFS	Median	All	0.804	0.691	.013	14	view →
HNSC	OS	Tertile	III,IV	0.445	0.688	.012	11	view →
STAD	DFS	Tertile	IV	0.087	0.562	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0002281–READ (DFS)

Open the READ breakdown →