Macrophage activation involved in immune response

Across TCGA patient cohorts, RNA activity of the Macrophage activation involved in immune response pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, STK10, and STAB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage activation involved in immune response activity versus RCSD1 in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1 →	+0.600	+0.065	<.001	<.001	3	10
HNSC	STK10 →	+0.464	+0.093	<.001	<.001	3	10
GBM	STAB1 →	+0.466	+0.070	<.001	<.001	3	10
GBM	GIMAP8 →	+0.490	+0.049	<.001	<.001	3	10
UCEC	IL16 →	+0.554	+0.064	<.001	.003	3	10
UCEC	PLEKHO2 →	+0.446	+0.110	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002281 vs RCSD1 — OV

Explore this scatter interactively →