Macrophage activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Macrophage activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1GAP2, RPL22L1, and TMEM248, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAP1GAP2 grouped by Macrophage activation involved in immune response-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RAP1GAP2 →	-1.779	-1.331	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	RPL22L1 →	+1.429	+1.277	<.001	.001	3	5
BONE	TMEM248 →	+0.929	+1.999	.001	<.001	3	4
KIDNEY	ZNF396 →	+0.656	+0.871	<.001	.006	3	4
CNS	LRRC6 →	+1.088	+1.284	.004	<.001	3	4
STOMACH	RRM2B →	+1.154	+1.195	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAP1GAP2 by Macrophage activation involved in immune response activity — PANCREAS

Explore this box plot interactively →