Macrophage activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Macrophage activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1, PSMB9, and APOL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage activation involved in immune response activity versus HNRNPA1 in LUNG_SCLC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HNRNPA1 →	+0.581	+0.248	<.001	.005	3	7
STOMACH	PSMB9 →	-2.440	-1.036	<.001	.004	3	6
BREAST	APOL3 →	-2.902	-0.509	<.001	.007	3	6
LUNG_SCLC	IRF9 →	-1.656	-0.327	.004	.001	2	7
STOMACH	RTP4 →	-1.745	-1.048	<.001	.003	3	5
BLOOD_Leukemia	SLC15A3 →	-1.440	-0.233	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002281 vs HNRNPA1 — LUNG_SCLC

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