Myeloid leukocyte activation

Across TCGA patient cohorts, RNA activity of the Myeloid leukocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAT1, XCL2, and XXYLT1-AS2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid leukocyte activation activity versus SAT1 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAT1 →	+0.829	+0.203	.001	.003	3	3
BRCA	XCL2 →	+1.371	+0.302	.008	.002	3	3
BRCA	XXYLT1-AS2 →	+0.542	+0.315	.007	.001	3	3
CCRCC	ALOX5AP →	+1.884	+0.332	.002	.006	3	3
COAD	SEC11A →	+0.413	+0.218	.007	.003	3	3
CCRCC	C1orf162 →	+0.639	+0.332	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002274 vs SAT1 — BRCA

Explore this scatter interactively →