Myeloid leukocyte activation

Across TCGA pan-cancer cohorts, RNA activity of the Myeloid leukocyte activation pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and LUAD, show the opposite pattern, with lower activity in tumor tissue.

COAD, KIRC, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Male	All	−0.028	<.001	10	view →
KIRC	All	All	+0.027	<.001	10	view →
LUAD	Male	II,III,IV	−0.034	<.001	9	view →
KICH	Male	II,III,IV	−0.032	<.001	9	view →
LUSC	Male	II,III,IV	−0.080	<.001	8	view →
LIHC	Male	All	−0.023	<.001	6	view →
BRCA	All	II,III,IV	−0.018	<.001	6	view →
HNSC	Female	III,IV	+0.032	.008	4	view →
STAD	All	All	+0.030	.008	2	view →
KIRP	Female	II,III,IV	−0.016	.046	2	view →
THCA	Male	IV	+0.040	.013	1	view →
READ	Female	All	−0.034	.026	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0002274–COAD

Open the COAD breakdown →