Myeloid leukocyte activation

Across TCGA cell cohorts, RNA activity of the Myeloid leukocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP8L, BMP8B, and NANS, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKAP8L grouped by Myeloid leukocyte activation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	AKAP8L →	+0.465	+0.699	<.001	.001	3	3
KIDNEY	BMP8B →	+1.543	+0.998	.002	.003	3	3
KIDNEY	NANS →	-0.902	-1.082	.005	.007	3	3
URINARY_TRACT	KITLG →	-1.790	-1.532	.006	<.001	3	3
LUNG_NSCLC_LUAD	RPS6KA2 →	-1.554	-0.396	.002	.006	3	3
OESOPHAGUS	ABCA2 →	+1.968	+0.217	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKAP8L by Myeloid leukocyte activation activity — CNS

Explore this box plot interactively →