Myeloid leukocyte activation

Across TCGA cell cohorts, RNA activity of the Myeloid leukocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMPD1, HOXB9, and NUP42, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid leukocyte activation activity versus SMPD1 in CNS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SMPD1 →	+1.064	+0.171	.002	.005	3	5
BLOOD_Lymphoma	HOXB9 →	+1.968	+0.321	.008	.003	2	6
SOFT_TISSUE	NUP42 →	+0.882	+0.327	.002	.003	3	4
BLOOD_Leukemia	ZDHHC12 →	+0.710	+0.253	<.001	<.001	3	4
BLOOD_Leukemia	LRG1 →	+2.058	+0.244	.001	.003	3	4
BLOOD_Leukemia	IL1RAP →	+1.568	+0.287	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002274 vs SMPD1 — CNS

Explore this scatter interactively →