Organ or tissue specific immune response

Across TCGA patient cohorts, RNA activity of the Organ or tissue specific immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBTF_S484, NIPBL_T735, and MDC1_S882, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organ or tissue specific immune response activity versus UBTF_S484 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBTF_S484 →	+0.653	+0.085	<.001	<.001	3	6
GBM	NIPBL_T735 →	+0.383	+0.077	<.001	<.001	3	6
PDAC	MDC1_S882 →	+0.445	+0.082	.001	<.001	3	6
OV	SEPTIN11 →	-0.388	-0.044	<.001	.001	3	5
PDAC	SEPTIN2 →	-0.203	-0.063	<.001	<.001	3	5
OV	CDC42EP1 →	-0.385	-0.039	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002251 vs UBTF_S484 — GBM

Explore this scatter interactively →