Organ or tissue specific immune response

Across TCGA cell cohorts, RNA activity of the Organ or tissue specific immune response pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPF1, EP300, and PPM1M, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HPF1 grouped by Organ or tissue specific immune response-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HPF1 →	+0.753	+1.124	.002	.002	3	4
STOMACH	EP300 →	+0.741	+0.204	.006	<.001	3	3
STOMACH	PPM1M →	+1.477	+0.212	.003	.003	3	3
STOMACH	NRTN →	+1.650	+0.244	.001	.001	3	3
SKIN	BABAM1 →	+0.549	+0.830	.001	.007	3	3
SKIN	TPRKB →	+0.504	+0.711	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HPF1 by Organ or tissue specific immune response activity — OESOPHAGUS

Explore this box plot interactively →