Organ or tissue specific immune response

Across TCGA cell cohorts, RNA activity of the Organ or tissue specific immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF14, NFATC2, and CDC25B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF14 grouped by Organ or tissue specific immune response-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KIF14 →	+0.725	+2.072	.004	.001	2	2
BREAST	NFATC2 →	+0.250	+2.072	.005	.001	2	1
BREAST	CDC25B →	+1.125	+2.072	.002	.001	2	1
BREAST	PCYT1B →	+0.198	+2.072	.002	.001	2	1
BREAST	ZNF423 →	+0.163	+2.072	.003	.001	2	1
BREAST	STMN2 →	+0.296	+2.072	.004	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF14 by Organ or tissue specific immune response activity — BREAST

Explore this box plot interactively →