Organ or tissue specific immune response

Across TCGA cell cohorts, RNA activity of the Organ or tissue specific immune response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSL, SH2D6, and GALNTL6, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organ or tissue specific immune response activity versus CTSL in BREAST (Pearson r = -0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CTSL →	-1.384	-1.958	.004	.006	1	2
BREAST	SH2D6 →	-0.535	-1.958	.002	.006	1	2
BREAST	GALNTL6 →	+0.159	+1.958	.009	.006	1	2
BREAST	SLITRK4 →	+0.324	+1.958	.005	.006	1	2
BREAST	SEC63 →	-0.869	-1.958	.002	.006	1	2
BREAST	UPB1 →	-0.385	-1.958	.004	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002251 vs CTSL — BREAST

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