Connective tissue replacement involved in inflammatory response wound healing

Across TCGA patient cohorts, RNA activity of the Connective tissue replacement involved in inflammatory response wound healing pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, RSU1, and PPFIBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Connective tissue replacement involved in inflammatory response wound healing activity versus NID2 in CCRCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NID2 →	+0.445	+0.066	<.001	<.001	3	8
BRCA	RSU1 →	+0.379	+0.083	<.001	<.001	3	8
LSCC	PPFIBP1 →	+0.343	+0.076	<.001	<.001	3	8
CCRCC	PPM1F →	+0.301	+0.068	<.001	.001	3	8
BRCA	CAV1 →	+0.639	+0.061	<.001	<.001	3	8
BRCA	LIMS1 →	+0.424	+0.083	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002248 vs NID2 — CCRCC

Explore this scatter interactively →