Hematopoietic progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAC9, FHL1, and MGP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic progenitor cell differentiation activity versus PLAC9 in PDAC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLAC9 →	-0.619	-0.851	<.001	<.001	3	4
PDAC	FHL1 →	-0.525	-0.673	<.001	.001	3	4
COAD	MGP →	-1.242	-1.021	.001	<.001	3	4
COAD	TNN →	-0.136	-0.696	.005	.002	3	4
CCRCC	HMGCS2 →	-1.589	-0.468	.006	.008	3	4
OV	FBXL16 →	-0.981	-0.665	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002244 vs PLAC9 — PDAC

Explore this scatter interactively →