Hematopoietic progenitor cell differentiation

Across TCGA cell cohorts, RNA activity of the Hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2A, TM9SF1, and STON2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic progenitor cell differentiation activity versus POLR2A in OESOPHAGUS (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	POLR2A →	-1.044	-1.068	.002	.001	3	3
OESOPHAGUS	TM9SF1 →	-0.813	-0.881	.004	.003	3	3
OESOPHAGUS	STON2 →	-2.308	-1.094	.001	.005	3	3
LUNG_NSCLC_LUAD	U2AF1 →	+0.417	+0.381	.003	.002	3	3
LUNG_NSCLC_LUAD	TMEM70 →	+0.690	+0.389	.005	.006	3	3
LUNG_NSCLC_LUAD	C1orf122 →	+0.584	+0.345	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002244 vs POLR2A — OESOPHAGUS

Explore this scatter interactively →