Response to molecule of fungal origin

Across TCGA patient cohorts, RNA activity of the Response to molecule of fungal origin pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAPG, COTL1, and EVI2B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to molecule of fungal origin activity versus CAPG in GBM (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CAPG →	+0.604	+0.137	<.001	<.001	3	10
LSCC	COTL1 →	+0.626	+0.137	<.001	<.001	3	10
LSCC	EVI2B →	+0.815	+0.132	<.001	<.001	3	10
GBM	GMIP →	+0.441	+0.118	<.001	<.001	3	10
GBM	LCP1 →	+0.967	+0.138	<.001	<.001	3	10
GBM	PTPN6 →	+0.795	+0.136	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002238 vs CAPG — GBM

Explore this scatter interactively →