Response to molecule of fungal origin

Across TCGA pan-cancer cohorts, RNA activity of the Response to molecule of fungal origin pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Response to molecule of fungal origin pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BLCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

BLCA, SKCM, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	All	0.542	0.305	<.001	91	view →
SKCM	OS	Median	All	0.430	0.262	<.001	91	view →
ESCA	OS	Tertile	All	0.836	0.558	<.001	70	view →
LGG	OS	Median	All	0.362	0.535	<.001	50	view →
UVM	DFS	Median	All	0.409	0.767	<.001	41	view →
LUAD	DFS	Median	All	0.741	0.600	<.001	38	view →
UCEC	DFS	Median	All	0.926	0.869	.005	30	view →
THYM	OS	Median	All	0.933	1.000	.005	29	view →
ACC	OS	Median	III,IV	0.182	0.764	.003	27	view →
LUSC	DFS	Quartile	III,IV	0.713	0.331	.005	25	view →
READ	OS	Median	III,IV	0.863	0.606	.002	25	view →
SARC	OS	Tertile	All	0.829	0.645	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0002238–BLCA (OS)

Open the BLCA breakdown →