Response to molecule of fungal origin

Across TCGA patient cohorts, RNA activity of the Response to molecule of fungal origin pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEI1, KLHL6, and IL2RB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to molecule of fungal origin activity versus MEI1 in HNSC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MEI1 →	+0.837	+0.175	<.001	.001	3	7
HNSC	KLHL6 →	+0.875	+0.345	<.001	<.001	3	7
CCRCC	IL2RB →	+0.975	+0.158	<.001	<.001	3	6
HNSC	TLR8 →	+0.793	+0.154	.001	<.001	3	6
HNSC	RASAL3 →	+0.762	+0.256	<.001	<.001	3	6
HNSC	CD2 →	+1.163	+0.144	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002238 vs MEI1 — HNSC

Explore this scatter interactively →