Response to molecule of fungal origin

Across TCGA cell cohorts, RNA activity of the Response to molecule of fungal origin pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX4I1, PPP1R14A, and ITGAV, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX4I1 grouped by Response to molecule of fungal origin-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	COX4I1 →	+0.408	+1.603	.002	.001	3	5
LUNG_NSCLC_LUAD	PPP1R14A →	+0.193	+1.089	.001	.001	3	5
LUNG_NSCLC_LUAD	ITGAV →	-0.441	-0.818	<.001	.008	3	4
LUNG_SCLC	INS →	+0.178	+1.653	.002	<.001	3	4
LUNG_NSCLC_LUSC	VCX2 →	+0.375	+2.018	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	EPB41L4B →	+0.188	+1.645	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX4I1 by Response to molecule of fungal origin activity — STOMACH

Explore this box plot interactively →