Leukocyte chemotaxis involved in inflammatory response

Across TCGA cell cohorts, RNA activity of the Leukocyte chemotaxis involved in inflammatory response pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTN, MDK, and PCDHGA1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTN grouped by Leukocyte chemotaxis involved in inflammatory response-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTN →	-0.298	-1.437	<.001	<.001	3	10
BREAST	MDK →	-0.506	-1.302	<.001	<.001	3	8
LUNG_SCLC	PCDHGA1 →	-0.490	-1.625	<.001	<.001	3	7
LUNG_SCLC	USP40 →	-0.401	-1.307	.001	.001	2	8
BLOOD_Leukemia	PPFIBP1 →	-0.425	-1.273	<.001	<.001	3	6
BLOOD_Leukemia	NINJ1 →	-0.255	-1.250	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTN by Leukocyte chemotaxis involved in inflammatory response activity — OVARY

Explore this box plot interactively →